Basaloidblue salivary gland tumors modern pathology. This paper provides recommendations on the assessment and management of patients with cancer originating from the salivary glands in the head and neck. Salivary gland tumors are variable in location, origin and malignant potential pathology. Acinic cell carcinoma 3% of all salivary gland neoplasm 8090% in parotid 15% of all parotid tumors mean age is 4050 years 23 occur in female 3% shows bilateral involvement second most common salivary gland tumor in children well circumscribed tumor with fibrosis tissue macroscopically. Longterm results are related to the grade of the cancer. Most salivary gland tumors are benign and occur in the parotid glands. A painless salivary mass is the most common sign and is evaluated by fineneedle aspiration biopsy. Ent surgeons excise them if a malignancy is suspected. Salivary gland tumor develops where there is abnormal growth of cells in the salivary glands and the ducts of the salivary glands through which the glands drain the saliva to the mouth. Salivary gland cancer is a rare disease in which malignant cancer cells form in the tissues of the salivary glands. They do not generally invade adjacent tissues or metastasize, but they can continue to grow and become deforming. About salivary gland cancer what is salivary gland cancer. Salivary gland tumorcausessymptomstreatmentprognosis.
Salivary gland cancers malignant salivary gland tumors there are many types of salivary gland cancers. Please use one of the following formats to cite this article in your essay, paper or report. Furthermore, some malignant salivary gland tumours are deemed to be caused by dedifferentiation or malignant transformation of benign tumours. There are a variety of benign salivary gland tumors, including. Salivary gland tumors ppt by dr gulzar a bhat authorstream. Investigations such as fine needle aspiration cytology and mri scans provide some useful information, but most cases will require surgical. Approaches to the diagnosis of salivary gland tumours salivary tumours are a particular challenge to the diagnostic pathologist. Salivary gland tumours are uncommon in children, representing only 1% of all childhood neoplasms and 10% of all paediatric head and neck tumours.
Salivary gland tumor an overview sciencedirect topics. Pdf salivary gland tumours are a relatively rare and morphologically diverse group of lesions. May be seen in association with dermal cylindromas in the context of a genetic mutation. According to data from the seven main dental schools in china, among 69 902 cases of oral and. The majority of the tumours occurred in the parotid gland 509, followed by the minor salivary glands 212, the submandibular gland 51 and lastly, the sublingual gland 7. Saliva has enzymes that help digest food and antibodies that help protect against infections of the mouth and throat.
The salivary glands make saliva and release it into the mouth. Salivary gland cancers are named according to which of these cell types they most look like when seen under a microscope. Portion of a parotid gland demonstrating multiple foci of sebaceous differentiation. Although, overall, tumours are more common in the parotid, the incidence of malignancy is higher in the submandibular and minor salivary glands. Histopathological evaluation of minor salivary gland. The minor salivary gland tumors msgts may be present in individuals of a wide age range including children and adults. The tumors can arise in about 80% in parotid gland, 15% in submandibular gland and 5% in the sublingual and minor salivary gland. Salivary gland tumours represent one of the most challenging areas in diagnostic head and neck pathology. In general, the ratio of benign to malignant tumors is proportional to the gland size. Of the 22 parotid benign pleo morphic adenomas, 16 were in the superficial lobe. Normal salivary glands are made up of many different kinds of cells, and tumors can start in any of these cell types. Salivary gland tumours represent about 6% of head and neck neoplasms and about 0.
Conservative and functional surgery in the treatment of. What is the most common benign salivary neoplasm for all salivary glands. The latest who classification has attempted to simplify the classification but there are still more than 30 tumours for the pathologist to grapple with. Salivary gland tumours are among the most common tumours in the oral and maxillofacial regions. There are numerous entities of salivary gland neoplasms and while. They were present in six cases ofpleomorphicadenomas. This paper provides recommendations on the assessment and management of patients with cancer originating from the salivary glands in. They represent less than one percent of all head and neck tumors. Salivary gland tumors are relatively uncommon and account for approximately 36% of all neoplasms of the head and neck. These rare tumours exhibit a diverse array of morphological features, such that there are currently over thirty subtypes in the current world health organisation who classi.
The main function of the salivary glands are to produce saliva, which cleans the mouth of any pathogens that might have infiltrated into the mouth by way of food and also helps in. They produce saliva, which moistens food to help with chewing and swallowing. Salivary gland tumours are a morphologically and clinically diverse group of neoplasms, which may present considerable diagnostic and management challenges to the pathologist or surgeon. Salivary gland tumors tehran university of medical sciences. This could be particularly important for aggressive salivary gland tumors, such as salivary duct carcinoma sdc. Salivary gland tumors are abnormal cells growing in the gland or in the tubes ducts that drain the salivary glands. Although most clinicians and pathologists will have encountered the more common benign neoplasms, few have experience of the full range of salivary cancers, which are best managed in specialist centres. Basaloid tumors 001applications of salivary tumor basics. Usually parotid gland, occasionally submandibular gland. Salivary gland tumors msd manual professional edition.
Salivary gland tumours are one of the most difficult areas of diagnostic pathology, with significant morphological diversity and many overlapping features. For malignant tumors, treatment is with excision and radiation. Salivary gland tumours most often present as painless enlarging masses. These are commonly seen in the cheek, palate, and lips. Malignant sgts represent 6% of head and neck cancers and 0. Worldwide annual incidence of salivary gland tumours varies from 0. Of these, five were tumours of minor salivary glands and all were from the palate. Approximately three fourths of all salivary gland tumors occur in the major salivary glands. Staging of definitive resections for primary salivary gland carcinoma and neuroendocrine carcinoma of the parotid, submandibular or sublingual gland should use this system on occasion it may be difficult to distinguish a sublingual salivary gland primary with certainty from a salivary gland tumor arising from minor salivary glands in the. The principal hurdle in their management lies in the difficulty in distinguishing benign from malignant tumours. Salivary gland tumours are rare with an overall incidence in the western world of about 2. Pathologic tnm staging of major salivary glands ajcc 8th.
Cancer of the major salivary glands is a heterogeneous disease with a low overall incidence. Salivary gland tumors sgts are rare neoplasms accounting for 0. Still in the us, carcinomas of the major salivary glands comprise 11% of. The majority of these tumors reoccur after curative surgical procedures. Tumour growth and malignant transformation are complex processes involving various actions of molecules. Salivary gland tumors sgts are usually in the parotid uncommon 5. Intraoral minor salivary gland tumors constitute both benign and malignant tumors of the minor salivary glands. Seroustype acini of a parotid gland with dense secretory granules histologic section of a submaxillary gland. Due to the size discrepancy, in absolute numbers the. The parotid is involved in up to 90% of cases, and approximately half are malignant, the majority of these occurring in children over 10 years of age. The remaining case of pleomorphic adenoma was from the right parotid gland. Salivary gland tumours are a relatively rare and morphologically diverse group of lesions.
Multiple tumours of the parotid gland the journal of. An approach to the why is salivary gland pathology. The major and minor salivary glands give rise to a variety of both benign and malignant lesions. This article will focus on some of the new advances in salivary gland tumor pathology that have a potential for clinical impact. Salivary gland tumours are rare and have very wide histological heterogeneity, thus making it difficult to generate high level evidence. Traditionally, the treatment of choice for these tumors is surgery. Benign and malignant salivary gland tumors anticancer research. Current concepts in diagnosis of unusual salivary gland tumors. The proper diagnosis of salivary glands neoplasms is complex, and the otorhinolaryngologisthead. Meenakshi suri, pathologist srl diagnostics, b 37, rama park, delhi110059 abstract introduction. Most of these tumors are benign not cancer, but the parotid glands still are where most malignant cancerous salivary gland tumors start. Most are located in the parotid glands and most are benign. The majority of salivary gland tumors are benign, meaning they are not cancers.
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